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Information About Psychtropic Drugs

What is Clozaril?
GENERIC NAME: Clozapine
BRAND NAMES: Clozaril, FazaClo, Clopine, Clozapine Synthon, Denzapine, Zaponex

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CLOZARIL is a chemical substance that crosses the blood-brain barrier and acts primarily upon the central nervous system where it affects brain function, resulting in changes in perception, mood, consciousness, cognition, and behavior. Clozaril also produces a range of physical side effects, as well as undesirable mental and physical manifestations when being discontinued. Because of these, Clozaril can be addictive. For information on how to to safely break the dependency on Clozaril or discontinue it under medical supervision, click here. For information on your rights if you or a family member is being urged to take Clozaril, click here.


INCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSIS. ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSIS TREATED WITH ANTIPSYCHOTIC DRUGS ARE AT AN INCREASED RISK OF DEATH. CLOZARIL®
(clozapine) IS NOT APPROVED FOR THE TREATMENT OF PATIENTS WITH DEMENTIA-RELATED PSYCHOSIS (SEE BOXED WARNING).

CLORAZIL SIDE EFFECTS: Agranulocytosis

Failure of the bone marrow to make enough white blood cells. A POTENTIALLY LIFE-THREATENING ADVERSE EVENT.


CLORAZIL SIDE EFFECTS: Seizures

A sudden attack, spasm, or convulsion.


CLORAZIL SIDE EFFECTS: Myocarditis

Myocarditis is an inflammation of the myocardium, the middle layer of the heart wall.


CLORAZIL SIDE EFFECTS: Orthostatic Hypotension

Relating to or caused by standing upright) Plummeting blood pressure that occurs when standing; dizziness and fainting.


CLORAZIL SIDE EFFECTS: Syncope

Temporary loss of consciousness.


CLORAZIL SIDE EFFECTS: Cardiac Arrest

Sudden cessation of heartbeat and cardiac function.


CLORAZIL SIDE EFFECTS: Drowsiness

A very sleepy state.


CLORAZIL SIDE EFFECTS: Headache

A pain located in the head, as over the eyes, at the temples, or at the base of the skull.

CLORAZIL SIDE EFFECTS: Constipation

Constipation is a decrease in the frequency of stool.


CLORAZIL SIDE EFFECTS: Fever

Abnormally high body temperature.


CLORAZIL SIDE EFFECTS: Fatigue

Physical or mental weariness.


CLORAZIL SIDE EFFECTS: Nausea

A feeling of sickness in the stomach characterized by an urge to vomit.


CLORAZIL SIDE EFFECTS: Weight gain

An increase in body weight that occurs when a person takes in more calories than the body needs or uses.


CLORAZIL SIDE EFFECTS: Hyperglycemia

An abnormally high level of glucose (sugar) in the blood.


CLORAZIL SIDE EFFECTS: Ketoacidosis

Glucose (a type of sugar) is the body's main energy source. But when the body can't use glucose for fuel - like when a person has untreated diabetes - the body breaks down fat for energy instead. When fat is broken down, the body produces chemicals called ketones, which appear in the blood and urine. High levels of ketones cause the blood to become more acidic. This is known as ketoacidosis.

CLORAZIL SIDE EFFECTS: Hyperosmolar coma

Diabetic hyperglycemic hyperosmolar coma is a complication of type 2 diabetes that involves extremely high blood sugar (glucose) levels without the presence of ketones. Ketones are a by-product of fat breakdown.


CLORAZIL SIDE EFFECTS: Death

The act of dying; the end of life; the total and permanent cessation of all the vital functions of an organism.


CLORAZIL SIDE EFFECTS: Diabetes mellitus

A condition in which the pancreas no longer produces enough insulin or cells stop responding to the insulin that is produced.


CLORAZIL SIDE EFFECTS: Neuroleptic malignant syndrome (NMS)

Is a life- threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic drugs. It generally presents with muscle rigidity, fever, autonomic instability and cognitive changes such as delirium.


CLORAZIL SIDE EFFECTS: Tardive Dyskinesia (TD)

Refers to a wide variety of involuntary, repetitive, persistent, stereotyped movements caused by the use of drugs.


CLORAZIL SIDE EFFECTS: Pulmonary embolus

A blood clot that has passed into and occluded the lung's pulmonary artery. An embolus causes an embolism. In this case, the embolus, a clot or foreign material, has been carried through the blood into the pulmonary artery or one of its branches, plugging the vessel.

CLORAZIL SIDE EFFECTS: Hepatitis

Inflammation of the liver, caused by infectious or toxic agents and characterized by jaundice, fever, liver.


CLORAZIL SIDE EFFECTS: Anticholinergic Toxicity

Physical effects resulting from agents that counter the action of acetylcholine, a neurotransmitter (chemical within the nervous system) that is involved in many major bodily functions. These effects typically include constipation, dry mouth, blurred vision, dizziness, and slowing of urination.

CLORAZIL SIDE EFFECTS: Dystonic symptoms

A state of abnormal tension or muscle tone. Includes: spasm of the neck muscles, sometimes progressing to tightness of the throat, swallowing.


CLORAZIL SIDE EFFECTS: Drowsiness/Sedation

A very sleepy state.

CLORAZIL SIDE EFFECTS: Dizziness

Refers to an impairment in spatial perception and stability.

CLORAZIL SIDE EFFECTS: Disturbed Sleep/Nightmares

A dream arousing feelings of intense fear, horror, and distress.

CLORAZIL SIDE EFFECTS: Hypokinesia

Abnormally decreased muscular movement.

CLORAZIL SIDE EFFECTS: Akinesia

Loss of normal motor function, resulting in impaired muscle movement.

CLORAZIL SIDE EFFECTS: Agitation

Extreme emotional disturbance.

CLORAZIL SIDE EFFECTS: Rigid/stiff muscles

Stiff or unyielding; not pliant or flexible muscles.


CLORAZIL SIDE EFFECTS: Weakness

The state or quality of being without strength or energy.


CLORAZIL SIDE EFFECTS: Ataxia

Loss of the ability to coordinate muscular movement.


CLORAZIL SIDE EFFECTS: Slurred speech

Abnormal speech in which words are not enunciated clearly or completely but are run together or partially eliminated.


CLORAZIL SIDE EFFECTS: Depression

Feelings of prolonged sadness.


CLORAZIL SIDE EFFECTS: Epileptiform Movements

Resembling that of epilepsy.

CLORAZIL SIDE EFFECTS: Myoclonic Jerks

A sudden twitching of muscles or parts of muscles, without any rhythm or pattern, occurring in various brain disorders.

CLORAZIL SIDE EFFECTS: Anxiety

A state of uneasiness and apprehension.


CLORAZIL SIDE EFFECTS: Nausea

A feeling of sickness in the stomach characterized by an urge to vomit.

CLORAZIL SIDE EFFECTS: Anorexia
Reduced appetite or total aversion to food. (possibly due to zinc deficiency).

CLOZARIL CLINICAL TRIALS

Functional division of hippocampal area CA1 via modulatory gating of entorhinal cortical inputs.
Ito HT, Schuman EM., Hippocampus. 2011 Jan 14. [Epub ahead of print]
Clozaril: 21240920 [Clozaril - as supplied by publisher] Related citations

Complete Resolution of Clozapine-Induced Sialorrhea with Low Dose Trihexyphenidyl.
Praharaj SK, Sarkhel S, Khanande RV, Sinha VK., Psychopharmacol Bull. 2010;43(4):73-75., Clozaril: 21240153 [Clozaril - as supplied by publisher]

Metabolic Syndrome with Different Antipsychotics: A Multicentre Cross-Sectional Study.
Cerit C, Vural M, Bos Gelmez SU, Ozten E, Aker AT, Yıldız M., Psychopharmacol Bull. 2010;43(4):22-36., Clozaril: 21240150 [Clozaril - as supplied by publisher]

Repeated phencyclidine administration alters glutamate release and decreases GABA markers in the prefrontal cortex of rats.
Amitai N, Kuczenski R, Behrens MM, Markou A., Neuropharmacology. 2011 Jan 13. [Epub ahead of print], Clozaril: 21238466 [Clozaril - as supplied by publisher] Related citations

Values of Using QTc and N-Terminal Fragment of B-Type Natriuretic Peptide as Markers for Early Detection of Acute Antipsychotic Drugs-Induced Cardiotoxicity.
Khalaf MA, Abdelrahman TM, Abbas MF., Cardiovasc Toxicol. 2011 Jan 14. [Epub ahead of print], Clozaril: 21234705 [Clozaril - as supplied by publisher]
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The quest for the pharmacological treatment of schizophrenia: from conventional neuroleptics to atypical antipsychotics and beyond.
Dratcu L., Vertex. 2010 Sep;XXI(93):385-393. Spanish., Clozaril: 21218203 [Clozaril - as supplied by publisher] Related citations

The role of serotonin in the NMDA receptor antagonist models of psychosis and cognitive impairment.
Meltzer HY, Horiguchi M, Massey BW., Psychopharmacology (Berl). 2011 Jan 8. [Epub ahead of print], Clozaril: 21212939 [Clozaril - as supplied by publisher]
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Association of weight gain and metabolic syndrome in patients taking clozapine: an 8-year cohort study.
Bai YM, Lin CC, Chen JY, Chen TT, Su TP, Chou P., J Clin Psychiatry. 2010 Nov 30. [Epub ahead of print], Clozaril: 21208584 [Clozaril - as supplied by publisher] Related citations

Evidence-based pharmacotherapy of schizophrenia.
Leucht S, Heres S, Kissling W, Davis JM., Int J Neuropsychopharmacol. 2011 Jan 6:1-16. [Epub ahead of print], Clozaril: 21208500 [Clozaril - as supplied by publisher] Related citations

Clozapine Plasma Level Monitoring for Prediction of Rehospitalization Schizophrenic Outpatients.
Stieffenhofer V, Saglam H, Schmidtmann I, Silver H, Hiemke C, Konrad A.
Pharmacopsychiatry. 2011 Jan 4. [Epub ahead of print], Clozaril: 21207352 [Clozaril - as supplied by publisher] Related citations

Schizophrenic disorders : The development of immunological concepts and therapy in psychiatry.
Himmerich H, Sorge S, Kirkby KC, Steinberg H., Nervenarzt. 2011 Jan 6. [Epub ahead of print] German., Clozaril: 21206999 [Clozaril - as supplied by publisher] Related citations

Evaluation of pax6 mutant rat as a model for autism.
Umeda T, Takashima N, Nakagawa R, Maekawa M, Ikegami S, Yoshikawa T, Kobayashi K, Okanoya K, Inokuchi K, Osumi N., PLoS One. 2010 Dec 21;5(12):e15500. Clozaril: 21203536 [Clozaril - in process]Free PMC ArticleFree text

Antagonist interaction with the human 5-HT(7) receptor mediates the rapid and potent inhibition of non-G-protein-stimulated adenylate cyclase activity: a novel GPCR effect.
Klein MT, Teitler M., Br J Pharmacol. 2010 Dec 30. doi: 10.1111/j.1476-5381.2010.01194.x. [Epub ahead of print], Clozaril: 21198551 [Clozaril - as supplied by publisher] Related citations

MMN responsivity to manipulations of frequency and duration deviants in chronic, clozapine-treated schizophrenia patients.
Horton J, Millar A, Labelle A, Knott VJ., Schizophr Res. 2010 Dec 29. [Epub ahead of print], Clozaril: 21194893 [Clozaril - as supplied by publisher]
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The impact of hospital smoking ban on clozapine and norclozapine levels.
Murayama-Sung L, Ahmed I, Goebert D, Alaimalo E, Sung H., J Clin Psychopharmacol. 2011 Feb;31(1):124-6. No abstract available., Clozaril: 21192157 [Clozaril - in process] Related citations

Erroneous administration of clozapine in a very elderly patient.
Palmiere C, Mangin P., J Clin Psychopharmacol. 2011 Feb;31(1):122-3. No abstract available., Clozaril: 21192156 [Clozaril - in process] Related citations

A meta-analysis of sexual dysfunction in psychiatric patients taking antipsychotics.
Serretti A, Chiesa A., Int Clin Psychopharmacol. 2010 Dec 28. [Epub ahead of print], Clozaril: 21191308 [Clozaril - as supplied by publisher] Related citations

Adolescent with treatment-refractory schizophrenia and clozapine-induced cardiomyopathy managed with high-dose olanzapine.
Bobb VT, Jarskog LF, Coffey BJ., J Child Adolesc Psychopharmacol. 2010 Dec;20(6):539-43. No abstract available., Clozaril: 21186975 [Clozaril - in process] Related citations

A pilot double-blind sham-controlled trial of repetitive transcranial magnetic stimulation for patients with refractory schizophrenia treated with clozapine.
de Jesus DR, Gil A, Barbosa L, Lobato MI, Magalhães PV, Favalli GP, Marcolin MA, Daskalakis ZJ, Belmonte-de-Abreu PD., Psychiatry Res. 2010 Dec 24. [Epub ahead of print], Clozaril: 21186062 [Clozaril - as supplied by publisher]
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Association between HTR2C polymorphisms and metabolic syndrome in patients with schizophrenia treated with atypical antipsychotics.
Bai YM, Chen TT, Liou YJ, Hong CJ, Tsai SJ., Schizophr Res. 2010 Dec 22. [Epub ahead of print], Clozaril: 21185157 [Clozaril - as supplied by publisher]
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The atypical anti-psychotic clozapine decreases bone mass in rats in vivo.
Costa JL, Smith G, Watson M, Lin JM, Callon K, Gamble G, Cheng A, Vickers MH, Shepherd PR, Cornish J, Grey A., Schizophr Res. 2010 Dec 22. [Epub ahead of print], Clozaril: 21185156 [Clozaril - as supplied by publisher]
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Interaction of clozapine and its nitrenium ion with rat D2 dopamine receptors: in vitro binding and computational study.
Dilly S, Liégeois JF., J Comput Aided Mol Des. 2010 Dec 24. [Epub ahead of print], Clozaril: 21184252 [Clozaril - as supplied by publisher] Related citations

Treatment of severe borderline personality disorder with clozapine.
Vohra AK., Indian J Psychiatry. 2010 Jul;52(3):267-9., Clozaril: 21180415 [Clozaril - in process]Free PMC ArticleFree text Related citations

Quetiapine in the treatment of psychosis in Parkinson's disease.
Shotbolt P, Samuel M, David A., Ther Adv Neurol Disord. 2010 Nov;3(6):339-50., Clozaril: 21179595 [Clozaril - in process]Free PMC ArticleFree text
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In Vivo Binding of Antipsychotics to D(3) and D(2) Receptors: A PET Study in Baboons with [(11)C]-(+)-PHNO.
Girgis RR, Xu X, Miyake N, Easwaramoorthy B, Gunn RN, Rabiner EA, Abi-Dargham A, Slifstein M., Neuropsychopharmacology. 2010 Dec 22. [Epub ahead of print], Clozaril: 21178982 [Clozaril - as supplied by publisher]
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Modulation of leptin by histamine H1 receptors as a novel therapeutic approach for treatment of clozapine induced seizure.
Ghanizadeh A., Psychiatr Danub. 2010 Dec;22(4):552-3. No abstract available.
Clozaril: 21169900 [Clozaril - in process] Related citations

Myoclonus as an indicator of infection in patients with schizophrenia treated with clozapine.
Liang CS, Hsieh TH., J Psychiatry Neurosci. 2011 Jan;36(1):E1-2. No abstract available., Clozaril: 21167107 [Clozaril - in process]Free PMC ArticleFree text
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Polypharmacy in schizophrenia.
Zink M, Englisch S, Meyer-Lindenberg A., Nervenarzt. 2010 Dec 17. [Epub ahead of print] German., Clozaril: 21165589 [Clozaril - as supplied by publisher] Related citations

Re: Recent case report of clozapine-induced acute hepatic failure.
Chaplin AC, Curley MA, Wanless IR., Can J Gastroenterol. 2010 Dec;24(12):739-40. No abstract available., Clozaril: 21165382 [Clozaril - in process] Related citations

Quantification of antidepressants and antipsychotics in human serum by precipitation and ultra high pressure liquid chromatography-tandem mass spectrometry.
Hasselstrøm J., J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Jan 1;879(1):123-8. Epub 2010 Dec 1., Clozaril: 21163713 [Clozaril - in process]
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The pharmacological management of violence in schizophrenia: a structured review.
Topiwala A, Fazel S., Expert Rev Neurother. 2011 Jan;11(1):53-63.
Clozaril: 21158555 [Clozaril - in process] Related citations

Off-label second generation antipsychotics for impulse regulation disorders: a review.
Beduin AS, de Haan L., Psychopharmacol Bull. 2010;43(3):45-81., Clozaril: 21150846 [Clozaril - in process]

Antipsychotic Occupancy of Dopamine Receptors in Schizophrenia.
Nord M, Farde L., CNS Neurosci Ther. 2010 Dec 8. doi: 10.1111/j.1755-5949.2010.00222.x. [Epub ahead of print], Clozaril: 21143431 [Clozaril - as supplied by publisher] Related citations

Dose-related effects of clozapine and risperidone on the pattern of brain regional serotonin and dopamine metabolism and on tests related to extrapyramidal functions in rats.
Batool F, Hasnat A, Haleem MA, Haleem DJ., Acta Pharm. 2010 Jun;60(2):129-40. Clozaril: 21134850 [Clozaril - in process] Related citations

The influence of N-desmethylclozapine and clozapine on recognition memory and BDNF expression in hippocampus.
Ertuğrul A, Ozdemir H, Vural A, Dalkara T, Meltzer HY, Saka E., Brain Res Bull. 2010 Dec 4. [Epub ahead of print], Clozaril: 21134422 [Clozaril - as supplied by publisher] Related citations

Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitization.
Ferguson SM, Eskenazi D, Ishikawa M, Wanat MJ, Phillips PE, Dong Y, Roth BL, Neumaier JF., Nat Neurosci. 2011 Jan;14(1):22-4. Epub 2010 Dec 5.
Clozaril: 21131952 [Clozaril - in process] Related citations

Spectrum of tardive syndromes: clinical recognition and management.
Bhidayasiri R, Boonyawairoj S., Postgrad Med J. 2010 Dec 3. [Epub ahead of print], Clozaril: 21131613 [Clozaril - as supplied by publisher] Related citations

Pharmacological characterizations of memantine-induced disruption of prepulse inhibition of the acoustic startle response in mice: Involvement of dopamine D(2) and 5-HT(2A) receptors.
Nakaya K, Nakagawasai O, Arai Y, Onogi H, Sato A, Niijima F, Tan-No K, Tadano T., Behav Brain Res. 2011 Mar 17;218(1):165-73. Epub 2010 Dec 3.
Clozaril: 21130810 [Clozaril - in process] Related citations

Olanzapine approved for the acute treatment of schizophrenia or manic/mixed episodes associated with bipolar I disorder in adolescent patients.
Maloney AE, Sikich L., Neuropsychiatr Dis Treat. 2010 Nov 10;6:749-66.
Clozaril: 21127693 [Clozaril - in process]Free PMC ArticleFree text Related citations

Tail suspension test does not detect antidepressant-like properties of atypical antipsychotics.
Wesołowska A, Partyka A, Jastrzębska-Więsek M, Kolarz A, Mierzejewski P, Bieńkowski P, Kołaczkowski M., Behav Pharmacol. 2010 Nov 30. [Epub ahead of print], Clozaril: 21127415 [Clozaril - as supplied by publisher] Related citations

Investigation on clozapine poisoning in one enterprise.
Jia HX, Shou WG, Xue ZY., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2010 Sep;28(9):718. Chinese. No abstract available., Clozaril: 21126500 [Clozaril - in process] Related citations

Differences in the diagnosis and treatment of immigrant and local psychiatric inpatients admitted to a general hospital in Spain: a controlled study.
Alda Díez M, García Campayo J, Sobradiel N., Actas Esp Psiquiatr. 2010 Sep-Oct;38(5):262-9. Epub 2010 Sep 1. English, Spanish., Clozaril: 21117000 [Clozaril - in process] Related citations

The effect of psychotropic drugs on cytochrome P450 2D (CYP2D) in rat brain.
Haduch A, Bromek E, Daniel WA., Eur J Pharmacol. 2011 Jan 25;651(1-3):51-8. Epub 2010 Nov 27., Clozaril: 21115002 [Clozaril - in process] Related citations

Switching from Brand-Name to Generic Psychotropic Medications: A Literature Review.
Desmarais JE, Beauclair L, Margolese HC., CNS Neurosci Ther. 2010 Nov 30. doi: 10.1111/j.1755-5949.2010.00210.x. [Epub ahead of print], Clozaril: 21114789 [Clozaril - as supplied by publisher] Related citations

Sensorimotor gating in NTS1 and NTS2 null mice: effects of d-amphetamine, dizocilpine, clozapine and NT69L.
Oliveros A, Heckman MG, Del Pilar Corena-McLeod M, Williams K, Boules M, Richelson E., J Exp Biol. 2010 Dec 15;213(Pt 24):4232-9., Clozaril: 21113004 [Clozaril - in process] Related citations

Risk Factors for Ileus in Patients with Schizophrenia.
Nielsen J, Meyer JM., Schizophr Bull. 2010 Nov 26. [Epub ahead of print]
Clozaril: 21112965 [Clozaril - as supplied by publisher] Related citations

Angioneurotic edema with risperidone: a case report and review of literature.
Soumya RN, Grover S, Dutt A, Gaur N., Gen Hosp Psychiatry. 2010 Nov-Dec;32(6):646.e1-3. Epub 2010 Apr 2., Clozaril: 21112458 [Clozaril - in process] Related citations

Topiramate augmentation in clozapine-treated patients with schizophrenia: clinical and metabolic effects.
Hahn MK, Remington G, Bois D, Cohn T., J Clin Psychopharmacol. 2010 Dec;30(6):706-10., Clozaril: 21105286 [Clozaril - in process] Related citations

Epileptic Seizures During Treatment with Antidepressants and Neuroleptics.
Steinert T, Baier H, Fröscher W, Jandl M., Fortschr Neurol Psychiatr. 2010 Nov 23. [Epub ahead of print], Clozaril: 21104599 [Clozaril - as supplied by publisher] Related citations

Clozapine imprinted polymers: synthesis, characterization and application for drug assay in human serum.
Mohajeri SA, Karimi G, Khansari MR., Anal Chim Acta. 2010 Dec 17;683(1):143-8. Epub 2010 Oct 21., Clozaril: 21094393 [Clozaril - in process]
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Release behaviour of clozapine matrix pellets based on percolation theory.
Aguilar-de-Leyva A, Sharkawi T, Bataille B, Baylac G, Caraballo I.
Int J Pharm. 2011 Feb 14;404(1-2):133-41. Epub 2010 Nov 19., Clozaril: 21094234 [Clozaril - in process] Related citations

Proteome analyses of cultured astrocytes treated with MK-801 and clozapine: similarities with schizophrenia.
Martins-de-Souza D, Lebar M, Turck CW., Eur Arch Psychiatry Clin Neurosci. 2010 Nov 19. [Epub ahead of print], Clozaril: 21088845 [Clozaril - as supplied by publisher] Related citations

Effect of antipsychotics on spontaneous hyperactivity and hypersensitivity to MK-801-induced hyperactivity in rats prenatally exposed to methylazoxymethanol.
Le Pen G, Jay TM, Krebs MO., J Psychopharmacol. 2010 Nov 18. [Epub ahead of print], Clozaril: 21088043 [Clozaril - as supplied by publisher] Related citations

Successful clozapine rechallenge after acute myocarditis.
Bray A, Reid R., Aust N Z J Psychiatry. 2011 Jan;45(1):90. Epub 2010 Nov 17. No abstract available., Clozaril: 21080852 [Clozaril - in process] Related citations

Protective Effect of Curcumin and its Combination with Piperine (Bioavailability Enhancer) Against Haloperidol-Associated Neurotoxicity: Cellular and Neurochemical Evidence.
Bishnoi M, Chopra K, Rongzhu L, Kulkarni SK., Neurotox Res. 2010 Nov 13. [Epub ahead of print], Clozaril: 21076901 [Clozaril - as supplied by publisher]
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D-isomer of gly-tyr-pro-cys-pro-his-pro peptide: a novel and sensitive in vitro trapping agent to detect reactive metabolites by electrospray mass spectrometry.
Laine JE, Auriola S, Pasanen M, Juvonen RO., Toxicol In Vitro. 2011 Feb;25(1):411-25. Epub 2010 Nov 12., Clozaril: 21075197 [Clozaril - in process] Related citations

Nonesterified cholesterol content of lysosomes modulates susceptibility to oxidant-induced permeabilization.
Reiners JJ Jr, Kleinman M, Kessel D, Mathieu PA, Caruso JA., Free Radic Biol Med. 2011 Jan 15;50(2):281-94. Epub 2010 Nov 11., Clozaril: 21074609 [Clozaril - in process] Related citations

Nitric oxide synthase inhibitors improve prepulse inhibition responses of Wistar rats.
Issy AC, Lazzarini M, Szawka RE, Carolino RO, Anselmo-Franci JA, Del Bel EA.
Behav Brain Res. 2011 Mar 1;217(2):416-23. Epub 2010 Nov 11.
Clozaril: 21074571 [Clozaril - in process] Related citations

Epigenetic GABAergic targets in schizophrenia and bipolar disorder.
Guidotti A, Auta J, Chen Y, Davis JM, Dong E, Gavin DP, Grayson DR, Matrisciano F, Pinna G, Satta R, Sharma RP, Tremolizzo L, Tueting P.
Neuropharmacology. 2010 Nov 11. [Epub ahead of print]
Clozaril: 21074545 [Clozaril - as supplied by publisher] Related citations

The metabolic syndrome and its constituting variables in atypical antipsychotic-treated subjects: Comparison with other drug treatments, drug-free psychiatric patients, first-degree relatives and the general population in Venezuela.
Baptista T, Serrano A, Uzcátegui E, Elfakih Y, Rangel N, Carrizo E, Fernández V, Connell L, de Baptista EA, Quiroz S, Uzcátegui M, Rondón J, Matos Y, Uzcátegui L, Gómez R, Valery L, Novoa-Montero D., Schizophr Res. 2010 Nov 9. [Epub ahead of print], Clozaril: 21071179 [Clozaril - as supplied by publisher]
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Clozapine versus other atypical antipsychotics for schizophrenia.
Asenjo Lobos C, Komossa K, Rummel-Kluge C, Hunger H, Schmid F, Schwarz S, Leucht S., Cochrane Database Syst Rev. 2010 Nov 10;11:CD006633. Review., Clozaril: 21069690 [Clozaril - indexed for MEDLINE] Related citations

Schizophrenia: The drug deadlock.
Abbott A., Nature. 2010 Nov 11;468(7321):158-9. No abstract available.
Clozaril: 21068804 [Clozaril - indexed for MEDLINE] Related citations

Toxic plasma concentration of clozapine in inflammatory processes.
van Gool AR, de Jong MH, Verhoeven WM., Tijdschr Psychiatr. 2010;52(11):791-6. Dutch., Clozaril: 21064022 [Clozaril - indexed for MEDLINE]Free Article Related citations

Clozapine screening: white bloodcell counts no longer sufficient.
Cohen D; Clozapinepluswerkgroep., Tijdschr Psychiatr. 2010;52(11):785-90. Dutch., Clozaril: 21064021 [Clozaril - indexed for MEDLINE]Free Article
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Risperidone-induced inactivation and clozapine-induced re-activation of rat cortical astrocyte 5-HT7 receptors: evidence for in situ GPCR homodimer protomer cross-talk.
Smith C, Toohey N, Klein MT, Knight JA, Teitler M., Mol Pharmacol. 2010 Nov 9. [Epub ahead of print], Clozaril: 21062995 [Clozaril - as supplied by publisher]Free Article Related citations

Data openness. Don't forget preclinical science.
Goudie AJ., BMJ. 2010 Nov 9;341:c6324. doi: 10.1136/bmj.c6324. No abstract available., Clozaril: 21062882 [Clozaril - indexed for MEDLINE] Related citations

Confounding factors for variation of clozapine plasma levels: drug interactions with proton pump inhibitor or infectious etiologies?
Wagner S, Varet-Legros MG, Fabre C, Montastruc JL, Bagheri H.
Eur J Clin Pharmacol. 2010 Nov 6. [Epub ahead of print] No abstract available.
Clozaril: 21057941 [Clozaril - as supplied by publisher] Related citations

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