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Information About Psychtropic Drugs

What is Nardil?
GENERIC NAME: Phenelzine
BRAND NAMES: Nardil

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NARDIL is a chemical substance that crosses the blood-brain barrier and acts primarily upon the central nervous system where it affects brain function, resulting in changes in perception, mood, consciousness, cognition, and behavior. Nardil also produces a range of physical side effects, as well as undesirable mental and physical manifestations when being discontinued. Because of these, Nardil can be addictive. For information on how to to safely break the dependency on Nardil or discontinue it under medical supervision, click here. For information on your rights if you or a family member is being urged to take Nardil, click here.

WARNINGS

 

Antidepressant medicines may increase suicidal thoughts or actions in some children, teenagers, and young adults within the first few months of treatment. 

Phenelzine may cause hypertensive crises, which have sometimes been fatal. These crises are characterized by some or all of the following symptoms: occipital headache which may radiate frontally, palpitation, neck stiffness or soreness, nausea, vomiting, sweating (sometimes with fever and sometimes with cold, clammy skin), dilated pupils and photophobia. Either tachycardia or bradycardia may be present and can be associated with constricting chest pain.

Intracranial bleeding has been reported in association with the increase in blood pressure. Blood pressure should be observed frequently to detect evidence of any pressor response (causing rise in blood pressure) in patients receiving phenelzine. Therapy should be discontinued immediately upon the occurrence of palpitation or frequent headaches during therapy.

The safe use of phenelzine during pregnancy or lactation has not been established. The potential benefit of this drug, if used during pregnancy, lactation, or in women of childbearing age, should be weighed against the possible hazard to the mother or fetus.

NARDIL SIDE EFFECT: Agitation

Extreme emotional disturbance.

NARDIL SIDE EFFECT: Allergic reactions

An abnormally high sensitivity to certain substances. Common Allergy symptoms include itching, skin rash, sneezing, runny nose, watering eyes, congestion, trouble breathing, abdominal pain, cramps, vomiting, diarrhea, mental confusion and dizziness.

NARDIL SIDE EFFECT: Anxiety

A state of uneasiness and apprehension.

NARDIL SIDE EFFECT: Ataxia

Loss of the ability to coordinate muscular movement.

NARDIL SIDE EFFECT: Blurred vision

Blurred vision is the loss of sharpness of vision and the inability to see small details.

NARDIL SIDE EFFECT: Chest pain

Discomfort or pain that you feel anywhere along the front of your body between your neck and upper abdomen.

NARDIL SIDE EFFECT: Coma

A state of deep and often prolonged unconsciousness.

NARDIL SIDE EFFECT: Constipation

Refers to bowel movements that are infrequent and/or hard to pass.

NARDIL SIDE EFFECT: Convulsions

A medical condition where body muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body.

NARDIL SIDE EFFECT: Depression

Feelings of prolonged sadness, loss of interest or pleasure in life.

NARDIL SIDE EFFECT: Dizziness

An impairment in spatial perception and stability.

NARDIL SIDE EFFECT: Drowsiness

A very sleepy state.

NARDIL SIDE EFFECT: Dry mouth

Inability to make saliva.

NARDIL SIDE EFFECT: Edema

A condition of abnormally large fluid volume in the circulatory system or in tissues between the body's cells.

NARDIL SIDE EFFECT: Fatigue

Physical or mental weariness.

NARDIL SIDE EFFECT: Fever

Abnormally high body temperature.

NARDIL SIDE EFFECT: Glaucoma

An eye disease that damages the optic nerve and impairs vision.

NARDIL SIDE EFFECT: Headache

A pain located in the head, as over the eyes, at the temples, or at the base of the skull.

NARDIL SIDE EFFECT: Hives

An allergic skin reaction causing localized redness, swelling, and itching.

NARDIL SIDE EFFECT: Hostility

The state of being hostile; antagonism or enmity.

NARDIL SIDE EFFECT: Hypermetabolic syndrome

An abnormal increase in metabolic rate usually accompanied by excessive body heat.

NARDIL SIDE EFFECT: Hypernatremia

An abnormally low concentration of sodium in the blood.

NARDIL SIDE EFFECT: Hyperpyrexia

Abnormally high fever.

NARDIL SIDE EFFECT: Hyperreflexia

Disordered response to stimuli characterized by exaggeration of reflexes.

NARDIL SIDE EFFECT: Hypotension

Low blood pressure, or hypotension, occurs when blood pressure during and after each heartbeat is much lower than usual. This means the heart, brain, and other parts of the body do not get enough blood.

NARDIL SIDE EFFECT: Hypoxia

An inadequate oxygen supply to the cells and tissues of the body.

NARDIL SIDE EFFECT: Insomnia

Inability to obtain sufficient sleep, esp. when chronic.

NARDIL SIDE EFFECT: Irritability

Easily irritated or annoyed.

NARDIL SIDE EFFECT: Itching

An irritating skin sensation causing a desire to scratch.

NARDIL SIDE EFFECT: Jaundice

Yellowish discoloration of the whites of the eyes, skin, and mucous membranes caused by deposition of bile salts in these tissues.

NARDIL SIDE EFFECT: Jitteriness

A state of extreme nervousness or nervous shaking.

NARDIL SIDE EFFECT: Leukopenia

An abnormally low number of white blood cells in the circulating blood.


NARDIL SIDE EFFECT: Lupus-like syndrome

A clinical syndrome resembling Lupus, an inflammatory connective tissue disease with variable features, frequently including fever, weakness and fatigue, joint pains or arthritis resembling rheumatoid arthritis, skin lesions on the face, neck, or upper extremities, and many other symtomes.

NARDIL SIDE EFFECT: Manic reaction

Excitement of psychotic nature manifested by mental and physical hyperactivity, disorganization of behavior and (extreme) elevation of mood.

NARDIL SIDE EFFECT: Myoclonic movements

Brief and rapid twitching of a muscle or muscle groups. The twitching or jerking happens suddenly and cannot be stopped or controlled at will.

NARDIL SIDE EFFECT: Nausea

A feeling of sickness in the stomach characterized by an urge to vomit.

NARDIL SIDE EFFECT: Nystagmus

A rapid, involuntary, oscillatory motion of the eyeball.

NARDIL SIDE EFFECT: Palilalia

A speech defect marked by abnormal repetition of syllables, words, or phrases.

NARDIL SIDE EFFECT: Panic attacks

The sudden onset of intense anxiety, characterized by feelings of intense fear and apprehension and accompanied by palpitations.

NARDIL SIDE EFFECT: Paresthesias

A skin sensation, such as burning, prickling, itching, or tingling, with no apparent physical cause.

NARDIL SIDE EFFECT: Pruritus

Severe itching, often of undamaged skin.

NARDIL SIDE EFFECT: Rash

A group of spots or red, inflamed skin.

NARDIL SIDE EFFECT: Severe anxiety

Extreme uneasiness and apprehension.

NARDIL SIDE EFFECT: Severe restlessness

Extreme inability to rest or relax; ceaselessly moving or active.

NARDIL SIDE EFFECT: Suicidal thoughts or behaviors

Having thoughts about suicide, or attempting to commit suicide.

NARDIL SIDE EFFECT: Tachycardia

Abnormally rapid heart rate.

NARDIL SIDE EFFECT: Tachypnea

Very rapid breathing.

NARDIL SIDE EFFECT: Tardive Diskinesia

A mostly irreversible neurological disorder of involuntary movements. There is no known effective treatment for tardive dyskinesia.


NARDIL SIDE EFFECT: Toxic delirium

Symptom of disordered mental status as a result of poisoning.

NARDIL SIDE EFFECT: Tremors

An unintentional (involuntary) trembling or shaking that may affect the muscles of any part of the body. Tremor is caused by the rapid alternating contraction and relaxation of muscles.

NARDIL SIDE EFFECT: Twitching

To move jerkily or spasmodically.

NARDIL SIDE EFFECT: Urinary retention

Holding urine in the bladder.

NARDIL SIDE EFFECT: Vomiting

To eject part or all of the contents of the stomach through the mouth, usually in a series of involuntary movements.

NARDIL SIDE EFFECT: Weakness

A loss of muscle strength, medically defined as a condition of being feeble, fragile, frail, or decrepit or lacking physical strength, energy, or vigor.

NARDIL SIDE EFFECT: Weight gain
An increase in body weight.

NARDIL CLINICAL TRIALS


Advances pertaining to the pharmacology and interactions of irreversible nonselective monoamine oxidase inhibitors.
Gillman PK., J Clin Psychopharmacol. 2011 Feb;31(1):66-74.
Nardil: 21192146 [Nardil - in process], Related citations

Gene expression profile analysis of genes in rat hippocampus from antidepressant treated rats using DNA microarray.
Lee JH, Ko E, Kim YE, Min JY, Liu J, Kim Y, Shin M, Hong M, Bae H.
BMC Neurosci. 2010 Nov 30;11:152., Nardil: 21118505 [Nardil - in process] Free PMC Article, Free full text Related citations

Treatment options for bipolar depression: a systematic review of randomized, controlled trials.
Vieta E, Locklear J, Günther O, Ekman M, Miltenburger C, Chatterton ML, Aström M, Paulsson B., J Clin Psychopharmacol. 2010 Oct;30(5):579-90.
Nardil: 20814319 [Nardil - in process], Related citations


Best practice guide for the treatment of nightmare disorder in adults.
Aurora RN, Zak RS, Auerbach SH, Casey KR, Chowdhuri S, Karippot A, Maganti RK, Ramar K, Kristo DA, Bista SR, Lamm CI, Morgenthaler TI; Standards of Practice Committee; American Academy of Sleep Medicine.
J Clin Sleep Med. 2010 Aug 15;6(4):389-401., Nardil: 20726290 [Nardil - indexed for MEDLINE] Free PMC Article, Free full text Related citations


Phenelzine-induced myocardial injury: a case report.
Ngo AS, Ho RY, Olson KR., J Med Toxicol. 2010 Dec;6(4):431-4., Nardil: 20652662 [Nardil - in process], Related citations

The antidepressant phenelzine protects neurons and astrocytes against formaldehyde-induced toxicity.
Song MS, Baker GB, Dursun SM, Todd KG., J Neurochem. 2010 Sep 1;114(5):1405-13. Epub 2010 Jun 12., Nardil: 20557421 [Nardil - indexed for MEDLINE], Related citations

Pharmacological interventions for borderline personality disorder.
Stoffers J, Völlm BA, Rücker G, Timmer A, Huband N, Lieb K., Cochrane Database Syst Rev. 2010 Jun 16;(6):CD005653. Review., Nardil: 20556762 [Nardil - indexed for MEDLINE], Related citations

Clinical pharmacology tyramine challenge study to determine the selectivity of the monoamine oxidase type B (MAO-B) inhibitor rasagiline.
Goren T, Adar L, Sasson N, Weiss YM., J Clin Pharmacol. 2010, Dec;50(12):1420-8. Epub 2010 May 5., Nardil: 20445015 [Nardil - in process]
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Widespread hypothalamic-pituitary-adrenocortical axis-relevant and mood-relevant effects of chronic fluoxetine treatment on glucocorticoid receptor gene expression in mice.
Heydendael W, Jacobson L., Eur J Neurosci. 2010 Mar;31(5):892-902.
Nardil: 20374287 [Nardil - indexed for MEDLINE], Related citations

A placebo-controlled trial of phenelzine, cognitive behavioral group therapy, and their combination for social anxiety disorder.
Blanco C, Heimberg RG, Schneier FR, Fresco DM, Chen H, Turk CL, Vermes D, Erwin BA, Schmidt AB, Juster HR, Campeas R, Liebowitz MR., Arch Gen Psychiatry. 2010 Mar;67(3):286-95., Nardil: 20194829 [Nardil - indexed for MEDLINE], Related citations

Pharmacologically induced/exacerbated restless legs syndrome, periodic limb movements of sleep, and REM behavior disorder/REM sleep without atonia: literature review, qualitative scoring, and comparative analysis.
Hoque R, Chesson AL Jr., J Clin Sleep Med. 2010 Feb 15;6(1):79-83. Review.
Nardil: 20191944 [Nardil - indexed for MEDLINE] Free PMC Article, Free full text Related citations

Comparative analysis of small molecules and histone substrate analogues as LSD1 lysine demethylase inhibitors.
Culhane JC, Wang D, Yen PM, Cole PA., J Am Chem Soc. 2010 Mar 10;132(9):3164-76., Nardil: 20148560 [Nardil - indexed for MEDLINE], Related citations

The alarm pheromone in male rats as a unique anxiety model: psychopharmacological evidence using anxiolytics.
Inagaki H, Kiyokawa Y, Takeuchi Y, Mori Y., Pharmacol Biochem Behav. 2010 Feb;94(4):575-9. Epub 2009 Dec 5., Nardil: 19969015 [Nardil - indexed for MEDLINE], Related citations

Transport of phenylethylamine at intestinal epithelial (Caco-2) cells: mechanism and substrate specificity.
Fischer W, Neubert RH, Brandsch M., Eur J Pharm Biopharm. 2010 Feb;74(2):281-9. Epub 2009 Dec 3., Nardil: 19962438 [Nardil - indexed for MEDLINE], Related citations

Lipopolysaccharide-induced epithelial monoamine oxidase mediates alveolar bone loss in a rat chronic wound model.
Ekuni D, Firth JD, Nayer T, Tomofuji T, Sanbe T, Irie K, Yamamoto T, Oka T, Liu Z, Vielkind J, Putnins EE., Am J Pathol. 2009 Oct;175(4):1398-409. Epub 2009 Sep 24., Nardil: 19779138 [Nardil - indexed for MEDLINE] Free PMC Article, Free full text Related citations

Atypical depression: useful concept, but it's time to revise the DSM-IV criteria.
Thase ME., Neuropsychopharmacology. 2009 Dec;34(13):2633-41. Epub 2009 Sep 9. Review., Nardil: 19741592 [Nardil - indexed for MEDLINE] Free Article
Related citations

Interactions between herbal medicines and prescribed drugs: an updated systematic review.
Izzo AA, Ernst E., Drugs. 2009;69(13):1777-98. doi: 10.2165/11317010-000000000-00000. Review., Nardil: 19719333 [Nardil - indexed for MEDLINE]
Related citations

Glucocorticoid status affects antidepressant regulation of locus coeruleus tyrosine hydroxylase and dorsal raphé tryptophan hydroxylase gene expression.
Heydendael W, Jacobson L., Brain Res. 2009 Sep 8;1288:69-78. Epub 2009 Jul 3., Nardil: 19577549 [Nardil - indexed for MEDLINE] Free PMC Article
Free full text Related citations

Recent advances in understanding and treating social anxiety disorder.
Westenberg HG., CNS Spectr. 2009 Feb;14(2 Suppl 3):24-33. Review.
Nardil: 19238127 [Nardil - indexed for MEDLINE], Related citations

Treatment-emergent sexual dysfunction related to antidepressants: a meta-analysis.
Serretti A, Chiesa A., J Clin Psychopharmacol. 2009 Jun;29(3):259-66. Review.
Nardil: 19440080 [Nardil - indexed for MEDLINE], Related citations

[Irreversible, non-selective monoamine oxidase inhibitors].
Castberg I, Spigset O., Tidsskr Nor Laegeforen. 2009 Apr 16;129(8):746-8. Norwegian., Nardil: 19373300 [Nardil - indexed for MEDLINE] Free Article
Related citations

Neurochemical effects of the monoamine oxidase inhibitor phenelzine on brain GABA and alanine: A comparison with vigabatrin.
Todd KG, Baker GB., J Pharm Pharm Sci. 2008 May 16;11(2):14s-21s.
Nardil: 19203467 [Nardil - indexed for MEDLINE] Free Article
Related citations

Antidepressant phenelzine alters differentiation of cultured human and mouse preadipocytes.
Chiche F, Le Guillou M, Chétrite G, Lasnier F, Dugail I, Carpéné C, Moldes M, Fève B., Mol Pharmacol. 2009 May;75(5):1052-61. Epub 2009 Feb 6.
Nardil: 19201819 [Nardil - indexed for MEDLINE] Free Article, Related citations

Antidepressant-associated mood elevations in bipolar II disorder compared with bipolar I disorder and major depressive disorder: a systematic review and meta-analysis.
Bond DJ, Noronha MM, Kauer-Sant'Anna M, Lam RW, Yatham LN.
J Clin Psychiatry. 2008 Oct;69(10):1589-601. Review., Nardil: 19192442 [Nardil - indexed for MEDLINE], Related citations

Association of changes in norepinephrine and serotonin transporter expression with the long-term behavioral effects of antidepressant drugs.
Zhao Z, Zhang HT, Bootzin E, Millan MJ, O'Donnell JM., Neuropsychopharmacology. 2009 May;34(6):1467-81. Epub 2008 Oct 15.
Nardil: 18923402 [Nardil - indexed for MEDLINE] Free PMC Article, Free full text Related citations

Carbonyl scavenger and antiatherogenic effects of hydrazine derivatives.
Galvani S, Coatrieux C, Elbaz M, Grazide MH, Thiers JC, Parini A, Uchida K, Kamar N, Rostaing L, Baltas M, Salvayre R, Nègre-Salvayre A., Free Radic Biol Med. 2008 Nov 15;45(10):1457-67. Epub 2008 Sep 9., Nardil: 18801426 [Nardil - indexed for MEDLINE], Related citations

Differential effects of imipramine and phenelzine on corticosteroid receptor gene expression in mouse brain: potential relevance to antidepressant response.
Heydendael W, Jacobson L., Brain Res. 2008 Oct 31;1238:93-107. Epub 2008 Aug 16., Nardil: 18761333 [Nardil - indexed for MEDLINE], Related citations

Long-term administration of monoamine oxidase inhibitors alters the firing rate and pattern of dopamine neurons in the ventral tegmental area.
Chenu F, El Mansari M, Blier P., Int J Neuropsychopharmacol. 2009 May;12(4):475-85. Epub 2008 Aug 13., Nardil: 18700056 [Nardil - indexed for MEDLINE], Related citations

Serotonin syndrome and the T102-->C polymorphism of the 5-HT2A receptor: a case report.
Lattanzi L, Danesi R, Lastella M, Mungai F, Di Paolo A, Tuccori M, Cassano GB, Del Tacca M., Bipolar Disord. 2008 Jul;10(5):655-6. No abstract available.
Nardil: 18657250 [Nardil - indexed for MEDLINE], Related citations

Limitation of adipose tissue enlargement in rats chronically treated with semicarbazide-sensitive amine oxidase and monoamine oxidase inhibitors.
Carpéné C, Abello V, Iffiú-Soltész Z, Mercier N, Fève B, Valet P., Pharmacol Res. 2008 Jun;57(6):426-34. Epub 2008 Apr 24., Nardil: 18539478 [Nardil - indexed for MEDLINE], Related citations

Differential regulation of central BDNF protein levels by antidepressant and non-antidepressant drug treatments.
Balu DT, Hoshaw BA, Malberg JE, Rosenzweig-Lipson S, Schechter LE, Lucki I.
Brain Res. 2008 May 23;1211:37-43. Epub 2008 Mar 21., Nardil: 18433734 [Nardil - indexed for MEDLINE] Free PMC Article, Free full text Related citations

Evolution of the clock from yeast to man by period-doubling folds in the cellular oscillator.
Klevecz RR, Li CM., Cold Spring Harb Symp Quant Biol. 2007;72:421-9. Review., Nardil: 18419300 [Nardil - indexed for MEDLINE] Free PMC Article, Free full text Related citations

Modulation of dopaminergic neurotransmission in rat striatum upon in vitro and in vivo diclofenac treatment.
Milusheva E, Baranyi M, Kittel A, Fekete A, Zelles T, Vizi ES, Sperlágh B.
J Neurochem. 2008 Apr;105(2):360-8. Epub 2007 Nov 25., Nardil: 18036194 [Nardil - indexed for MEDLINE] Free PMC Article, Free full text Related citations

Not all monoamine oxidase inhibitors are created equal.
Stewart JT., J Am Geriatr Soc. 2007 Nov;55(11):1890. No abstract available.
Nardil: 17979910 [Nardil - indexed for MEDLINE], Related citations

The monoamine oxidase inhibitor phenelzine enhances the discriminative stimulus effect of nicotine in rats.
Wooters TE, Bardo MT., Behav Pharmacol. 2007 Nov;18(7):601-8., Nardil: 17912044 [Nardil - indexed for MEDLINE], Related citations

Transdermal selegiline for the treatment of major depressive disorder.
Lee KC, Chen JJ., Neuropsychiatr Dis Treat. 2007;3(5):527-37., Nardil: 19300583 [Nardil - in process] Free PMC Article, Free full text Related citations

Unlike lithium, anticonvulsants and antidepressants do not alter rat brain myo-inositol.
McGrath BM, Greenshaw AJ, McKay R, Slupsky CM, Silverstone PH.
Neuroreport. 2007 Oct 8;18(15):1595-8., Nardil: 17885608 [Nardil - indexed for MEDLINE], Related citations

Lithium augmentation compared with phenelzine in treatment-resistant depression in the elderly: an open, randomized, controlled trial.
Kok RM, Vink D, Heeren TJ, Nolen WA., J Clin Psychiatry. 2007 Aug;68(8):1177-85., Nardil: 17854241 [Nardil - indexed for MEDLINE]
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Acute myocarditis after massive phenelzine overdose.
Waring WS, Wallace WA., Eur J Clin Pharmacol. 2007 Nov;63(11):1007-9. Epub 2007 Sep 7., Nardil: 17823790 [Nardil - indexed for MEDLINE]
Related citations

Amine oxidases and their inhibitors: what can they tell us about neuroprotection and the development of drugs for neuropsychiatric disorders?
Baker GB, Sowa B, Todd KG., J Psychiatry Neurosci. 2007 Sep;32(5):313-5. No abstract available., Nardil: 17823646 [Nardil - indexed for MEDLINE] Free PMC Article, Free full text Related citations

Phenelzine causes an increase in brain ornithine that is prevented by prior monoamine oxidase inhibition.
MacKenzie EM, Grant SL, Baker GB, Wood PL., Neurochem Res. 2008 Mar;33(3):430-6. Epub 2007 Aug 31., Nardil: 17768678 [Nardil - indexed for MEDLINE], Related citations

Post-traumatic stress disorder: an evaluation of existing pharmacotherapies and new strategies.
Zhang W, Davidson JR., Expert Opin Pharmacother. 2007 Aug;8(12):1861-70. Review., Nardil: 17696789 [Nardil - indexed for MEDLINE], Related citations

Efficacy and safety of antidepressant monotherapy in the treatment of bipolar-II depression.
Agosti V, Stewart JW., Int Clin Psychopharmacol. 2007 Sep;22(5):309-11.
Nardil: 17690600 [Nardil - indexed for MEDLINE], Related citations

Serotonin syndrome in elderly patients treated for psychotic depression with atypical antipsychotics and antidepressants: two case reports.
Kohen I, Gordon ML, Manu P., CNS Spectr. 2007 Aug;12(8):596-8.
Nardil: 17667887 [Nardil - indexed for MEDLINE] Free Article, Related citations

Treating DSM-IV depression with atypical features.
Stewart JW, Thase ME., J Clin Psychiatry. 2007 Apr;68(4):e10. Review.
Nardil: 17474800 [Nardil - indexed for MEDLINE], Related citations

Translating the evidence on atypical depression into clinical practice.
Hyman Rapaport M., J Clin Psychiatry. 2007;68 Suppl 3:31-6. Review.
Nardil: 17348765 [Nardil - indexed for MEDLINE], Related citations

Treating depression with atypical features.
Stewart JW., J Clin Psychiatry. 2007;68 Suppl 3:25-9. Review., Nardil: 17348764 [Nardil - indexed for MEDLINE], Related citations

Successful use of phenelzine in treatment-resistant panic disorder.
Buch S, Wagner M., J Clin Psychiatry. 2007 Feb;68(2):335-6. No abstract available., Nardil: 17335337 [Nardil - indexed for MEDLINE], Related citations

Increased nicotine self-administration following prenatal exposure in female rats.
Levin ED, Lawrence S, Petro A, Horton K, Seidler FJ, Slotkin TA., Pharmacol Biochem Behav. 2006 Nov;85(3):669-74. Epub 2006 Dec 28., Nardil: 17196243 [Nardil - indexed for MEDLINE] Free PMC Article, Free full text Related citations

Post-traumatic stress disorder.
Bisson JI., Clin Evid (Online). 2007 Aug 1;2007. pii: 1005., Nardil: 19454111 [Nardil - in process], Related citations

 

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