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Information About Psychtropic Drugs

What is Parnate?
GENERIC NAME: Tranylcypromine
BRAND NAMES: Parnate

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PARNATE is a chemical substance that crosses the blood-brain barrier and acts primarily upon the central nervous system where it affects brain function, resulting in changes in perception, mood, consciousness, cognition, and behavior. Parnate also produces a range of physical side effects, as well as undesirable mental and physical manifestations when being discontinued. Because of these, Parnate can be addictive. For information on how to to safely break the dependency on Parnate or discontinue it under medical supervision, click here. For information on your rights if you or a family member is being urged to take Parnate, click here.

Warnings

 

Antidepressant medicines may increase suicidal thoughts or actions in some children, teenagers, and young adults.

PARNATE should not be administered in combination with any SSRI or SNRI. There have been reports of serious, sometimes fatal, reactions (including hyperthermia, rigidity, myoclonus, autonomic instability with possible rapid fluctuations of vital signs, and mental status changes that include extreme agitation progressing to delirium and coma) in patients receiving a SSRI (e.g., fluoxetine, Prozac®) or a SNRI (e.g., venlafaxine, Effexor®, Effexor XR®, Wyeth) in combination with a monoamine oxidase inhibitor.

PARNATE should not be used in combination with buspirone HCl, since several cases of elevated blood pressure have been reported in patients taking MAO inhibitors who were then given buspirone HCl.

Use of sympathomimetics and compounds such as guanethidine, methyldopa, reserpine, dopamine, levodopa, and tryptophan with PARNATE may precipitate hypertension, headache, and related symptoms. Cerebral hemorrhage may also occur.

Do not use meperidine concomitantly with MAO inhibitors or within 2 or 3 weeks following MAOI therapy. Serious reactions have been precipitated with concomitant use, including coma, severe hypertension or hypotension, severe respiratory depression, convulsions, malignant hyperpyrexia, excitation, peripheral vascular collapse, and death.

The use of Parnate in combination with cheese or other foods with a high tyramine content may cause fatal hypertension. Avoid the following foods:
• all matured or aged cheeses (note: all cheeses are considered matured or aged except fresh cottage cheese, cream cheese, ricotta, and processed cheese. All non-cheese dairy products can be consumed providing they are fresh)
• all aged, cured or fermented meat, fish, or poultry (note: meat, fish, or poultry that has not undergone aging, curing or fermenting and that is bought fresh, stored correctly and eaten fresh is not contraindicated)
• all fermented soybean products (e.g., soy sauce, miso, fermented tofu)
• sauerkraut
• fava or broad bean pods
• banana peel (but not the pulp)
• concentrated yeast extracts (e.g., Marmite or Vegemite spread)
• all tap/draught beers (note: some bottled beers, including non-alcoholic beer, may also pose a risk).

Patients should be advised to minimize or avoid use of all alcoholic beverages while taking Parnate.

The most important reaction associated with PARNATE is the occurrence of hypertensive crises which have sometimes been fatal. These crises are characterized by some or all of the following symptoms: occipital headache which may radiate frontally, palpitation, neck stiffness or soreness, nausea or vomiting, sweating (sometimes with fever and sometimes with cold, clammy skin), and photophobia. Either tachycardia or bradycardia may be present, and associated constricting chest pain and dilated pupils may occur. Intracranial bleeding, sometimes fatal in outcome, has been reported in association with the paradoxical increase in blood pressure.
Safety and effectiveness in the pediatric population have not been established.

PARNATE SIDE EFFECT: Bizarre behavior

Odd, strange, deviant, and abnormal actions and reactions.

PARNATE SIDE EFFECT: Blurred vision

Blurred vision is the loss of sharpness of vision and the inability to see small details.

PARNATE SIDE EFFECT: Chest pain

Discomfort or pain that you feel anywhere along the front of your body between your neck and upper abdomen.

PARNATE SIDE EFFECT: Constipation

Refers to bowel movements that are infrequent and/or hard to pass.

PARNATE SIDE EFFECT: Dark urine

Urine that is a deeper (usually brown, deep yellow or maroon) color rather than the usual straw to yellow color.

PARNATE SIDE EFFECT: Diarrhea

Excessive and frequent evacuation of watery feces, usually indicating gastrointestinal distress or disorder.

PARNATE SIDE EFFECT: Difficulty breathing

Labored, or uncomfortable breathing; shortness of breath; the feeling that one cannot get enough air.

PARNATE SIDE EFFECT: Difficulty sleeping

The perception or complaint of inadequate or poor-quality sleep because of one or more of the following: difficulty falling asleep; waking up frequently during the night with difficulty returning to sleep; waking up too early in the morning; or unrefreshing sleep. Also called insomnia.

PARNATE SIDE EFFECT: Dilated pupils

An abnormal condition where the iris of the eye opens excessively allowing more light onto the pupil.

PARNATE SIDE EFFECT: Dizziness

Having a sensation of whirling and a tendency to fall.

PARNATE SIDE EFFECT: Drowsiness

Drowsiness refers to feeling abnormally sleepy during the day. People who are drowsy may fall asleep in inappropriate situations or at inappropriate times.

PARNATE SIDE EFFECT: Dry mouth

Inability to make saliva.

PARNATE SIDE EFFECT: Fainting

Loss of consciousness caused by a temporary lack of oxygen to the brain.

PARNATE SIDE EFFECT: Fast, slow, or irregular heartbeat

Also called arrhythmia, this is an abnormal heart rhythm. The heartbeats may be irregular or too slow, or too rapid. Arrhythmia may predispose the patient to potentially life threatening conditions including stroke, embolism, cardiac arrest or sudden death.

PARNATE SIDE EFFECT: Feelings of irritability and hostility

The state of being easily annoyed and antagonistic.

PARNATE SIDE EFFECT: Fever

Abnormally high body temperature.

PARNATE SIDE EFFECT: Headache

A pain located in the head, as over the eyes, at the temples, or at the base of the skull.

PARNATE SIDE EFFECT: Hives

An allergic skin reaction causing localized redness, swelling, and itching.

PARNATE SIDE EFFECT: Impulsive behavior or other unusual changes in behavior

Acting without thinking or in ways which are unusual and uncharacteristic for the individual.

PARNATE SIDE EFFECT: Itching

An irritating skin sensation causing a desire to scratch.

PARNATE SIDE EFFECT: Nausea

A feeling of sickness in the stomach characterized by an urge to vomit.

PARNATE SIDE EFFECT: New or worsening mental or mood changes (eg, agitation, anxiety, depression)

When the original problem for which the drug is taken is magnified and made worse and other additional mental problems are added to the original one.

PARNATE SIDE EFFECT: Panic attacks

The sudden onset of intense anxiety, characterized by feelings of intense fear and apprehension and accompanied by palpitations.


PARNATE SIDE EFFECT: Pounding in the chest

Heart palpitations, when the heart feels like it is pounding.

PARNATE SIDE EFFECT: Rash

A group of spots or red, inflamed skin.


PARNATE SIDE EFFECT: Seizures

A sudden attack, spasm, or convulsion.

PARNATE SIDE EFFECT: Sensitivity to light

Photosensitivity (or sun sensitivity) is inflammation of the skin induced by the combination of sunlight and certain medications.


PARNATE SIDE EFFECT: Severe allergic reactions

A life threatening reaction to the drug. For example a feeling of uneasiness, followed by tingling sensations and dizziness, followed by generalized itching and hives, wheezing and difficulty breathing, fainting, or a combination of these and other allergy symptoms. These reactions can quickly become life threatening.

PARNATE SIDE EFFECT: Severe nervousness

Extreme uneasiness and apprehension.

PARNATE SIDE EFFECT: Severe restlessness

Extreme inability to rest or relax; ceaselessly moving or active.


PARNATE SIDE EFFECT: Shaking (tremor)

The involuntary trembling or shaking of the body. Often it affects the fingers or hands.

PARNATE SIDE EFFECT: Shivering

To shake, quiver, vibrate as if from cold, but in this case as a reaction to this drug.

PARNATE SIDE EFFECT: Sleeplessness

Inability to sleep.

PARNATE SIDE EFFECT: Sore or stiff neck

Neck painful or neck muscles tight.

PARNATE SIDE EFFECT: Stomach pain

An ache localized in the stomach or abdominal region.

PARNATE SIDE EFFECT: Sweating (sometimes with fever or cold, clammy skin)

Prespiring, either with an abnormal high temperature or an abnormal low temperature and damp skin.

PARNATE SIDE EFFECT: Swelling of the mouth,face, lips, or tongue Swelling is the enlargement of a body part or organ beyond it normal size and usually causing a distortion of the shape and structure of the affected area

PARNATE SIDE EFFECT: Swollen ankles/legs

Ankles and legs becoming puffed up with fluids, a condition which can become painful.

PARNATE SIDE EFFECT: Thoughts of suicide

Having thoughts about suicide.

PARNATE SIDE EFFECT: Tightness in the chest

A tightness, heavy pressure, or squeezing sensation in the chest.

PARNATE SIDE EFFECT: Tremors

An unintentional (involuntary) trembling or shaking that may affect the muscles of any part of the body. Tremor is caused by the rapid alternating contraction and relaxation of muscles.

PARNATE SIDE EFFECT: Unusual weight gain

An increase in body weight which is abnormal for the individual.

PARNATE SIDE EFFECT: Upset stomach

Pains and discomfort in the abdomen.

PARNATE SIDE EFFECT: Vision changes (e.g., double/blurred vision) May involve loss of vision or distortion of vision. E.g. blurriness, blind spots, halos around lights, or dimness of vision.

PARNATE SIDE EFFECT: Vomiting

Ejecting part or all of the contents of the stomach through the mouth, usually in a series of involuntary movements.

PARNATE SIDE EFFECT: Weakness

A loss of muscle strength, medically defined as a condition of being feeble, fragile, frail, or decrepit or lacking physical strength, energy, or vigor

PARNATE SIDE EFFECT: Yellowing eyes/skin
Yellowish discoloration of the whites of the eyes, skin, and mucous membranes caused by deposition of bile salts in these tissues. Also know as Jaundice.

 

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